Established during infancy, the initial colonisation and development of the complex gut microbial community of our gastrointestinal tract can be shaped by common medical interventions, such as caesarean section and antibiotic use. This chapter provides evidence on the gut microbial impact of four medical interventions: (1) caesarean delivery, (2) maternal intrapartum antibiotic prophylaxis (IAP), (3) hospitalisation post birth, and (4) postnatal infant antibiotic treatment. Reductions in bifidobacteria and members of the Bacteroidaceae family (e.g. Bacteroides fragilis) are by far the most common perturbations in microbial composition following each of these interventions, especially after elective or emergency caesarean section. On the other hand, genus Clostridium and the Enterbacteriaceae (e.g. Klebsiella, Escherichia coli) are likely to become more abundant in infants delivered by caesarean, exposed to maternal antibiotics, hospitalised post birth and treated with antibiotics. Often, the enterococci and staphylococci also become more abundant. Differential impact on gut microbiota is observed by type of caesarean delivery and antibiotic administered to the mother or infant. IAP with penicillin or cefazolin, or newborn treatment with intravenous penicillin (plus gentamicin) is associated with higher abundance of Enterococcus and Staphylococcus aureus. Klebsiella emerge after newborn intravenous ampicillin (plus gentamicin) treatment. The Veillonella become more abundant in the infant gut after emergency (but not elective caesarean), whereas they are found to be depleted two months after newborn treatment with oral cephalexin. Of note, dysbiosis from perinatal medical interventions also occurs in the early breastfed infant and is enhanced by prematurity.
Microbiota in health and disease: from pregnancy to childhood
EditorsPamela D. Browne, Eric Claassen and Michael D. Cabana
Published: 2017 Pages: 344
eISBN: 978-90-8686-839-1 | ISBN: 978-90-8686-294-8
Book Type: Edited Collection
Chapter 4 The impact of birth and postnatal medical interventions on infant gut microbiota
A.L. Kozyrskyj Related information
1Department of Pediatrics, University of Alberta, 3-527 Edmonton Clinic Health Academy, 11405 87th Avenue, Edmonton, AB T6G IC9, Canada.
*Corresponding author: kozyrsky@ualberta. ca
, S.L. Bridgman Related information*Corresponding author: kozyrsky@ualberta.
1Department of Pediatrics, University of Alberta, 3-527 Edmonton Clinic Health Academy, 11405 87th Avenue, Edmonton, AB T6G IC9, Canada.
, M.H. Tun Related information2School of Public Health, University of Alberta, 3-300 Edmonton Clinic Health Academy, 11405 87th Avenue Edmonton, AB T6G IC9, Canada.
Pages: 79 - 104
Published Online: July 14, 2017
Abstract: