Although the black soldier fly frass fertiliser (BSFFF) is globally recognised as a promising and potential high-quality organic fertiliser, there is inadequate information on its impact on the growth performance and nutritional status of maize. Furthermore, no information exist on their combination with mineral fertiliser (NPK) as well as economic impact on maize production. This study evaluated the comparative impact of BSFFF, NPK and commercial organic fertiliser (Evergrow^®) on growth, nitrogen use efficiency, yield, nutritional quality, and profitability of maize under greenhouse conditions. The treatments included: (1) sole application of BSFFF, conventional compost of brewers’ spent grain (BSG), Evergrow, and NPK at rates equivalent to 100 kg nitrogen (N) per hectare; (2) BSFFF and BSG combined with NPK so that each fertiliser supplies 50% of the N required; and (3) the control (unamended soil). Our findings revealed that BSFFF increased maize grain yield at higher rates: 2-25, 25-113 and 153-212% than NPK, BSG and Evergrow, respectively. Similarly, the BSF frass application led to higher maize growth and yield than the control treatment. The agronomic N use efficiency of maize grown using BSFFF was 2 and 3 times higher compared to that of BSG and Evergrow, respectively. Maize grown using BSFFF and NPK had higher crude protein and crude fibre content compared to the other treatments. The net income generated from the commercialisation of maize grown using a combination of BSFFF and NPK was 2, 163 and 173% higher than those achieved using sole NPK, mixture of BSG and NPK, and sole BSFFF, respectively. Our results imply that developing and promoting BSFFF alone or in integration with NPK can enhance the food security and livelihoods of smallholders, while safeguarding planetary health.