Mycotoxins are important food contaminants posing a significant threat to food and feed safety and public health. Among the mycotoxins, aflatoxins are deemed to be a more significant contaminant due to their potent carcinogenic, and hepatotoxic effects, and their levels are highly regulated in the international food trade. Phytochemicals are considered a major source of natural antifungal agents. The volatile nature of essential oil of plants makes them ideal candidates for antifungal agents due to their ability to distribute in free air spaces in closed containers and penetrate through heterogeneous food materials. In these, essential oils in spices attain special attention due to their commercial availability and low toxicity. This article reviews the antiaflatoxigenic capacity of spice essential oils and the effect of essential oil composition on the activity and mechanism of antifungal action and is expected to be useful for the planning of further research in the subject area.