A genome-wide association analysis was performed to identify genomic windows and the underlying positional candidate genes associated with feet and legs malformation (FL) in Nellore cattle. Single Nucleotide Polymorphism (SNP) effects were estimated from 295,031 pedigree records from animals with phenotypes, 12,537 genotypes for FL and 461,057 SNPs from the Alliance Nellore database using the weighted single-step genomic BLUP method. Twelve non-overlapping windows of 20 adjacent SNPs that explained more than 1% of the additive genetic variance were selected for candidate gene annotation. Functional and gene prioritization analysis of the candidate genes identified four genes (ATG7, EXT1, ITGA1, PPARD), previously reported in dairy and beef cattle populations, with a known role in skeletal muscle development, aberrant bone growth, lipid metabolism and intramuscular fat deposition. These candidate genes are believed to be associated with the incidence of FL in Nellore cattle.
Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP)
Technical and species orientated innovations in animal breeding, and contribution of genetics to solving societal challenges
EditorsR.F. Veerkamp and Y. de Haas
Published: 2022 Pages: 3364
eISBN: 978-90-8686-940-4
Book Type: Conference Proceedings
383. Genetic mechanisms underlying feet and legs malformation in Nellore cattle: prioritization of GWAS results
T.L. Silva Related information
1Department of Animal Science, Sao Paulo State University, School of Agriculture and Veterinarian Sciences, Jaboticabal, Brazil.
*Corresponding author: tl.
, C. Gondro Related information*Corresponding author: tl.
2College of Agriculture and Natural Resources, Department of Animal Science, Michigan State University, East Lansing, MI, 48824, USA.
, P.A.S. Fonseca Related information3Department of Animal Biosciences, Centre for Genetic Improvement of Livestock, University of Guelph, N1G 2W1, Guelph, Canada.
, D.A. da Silva Related information1Department of Animal Science, Sao Paulo State University, School of Agriculture and Veterinarian Sciences, Jaboticabal, Brazil.
, G. Vargas Related information1Department of Animal Science, Sao Paulo State University, School of Agriculture and Veterinarian Sciences, Jaboticabal, Brazil.
, H.H.R. Neves Related information4Gensys Associated Consultants, 90680-000 Porto Alegre, Brazil.
, I. Carvalho Filho Related information1Department of Animal Science, Sao Paulo State University, School of Agriculture and Veterinarian Sciences, Jaboticabal, Brazil.
, C.S. Teixeira Related information1Department of Animal Science, Sao Paulo State University, School of Agriculture and Veterinarian Sciences, Jaboticabal, Brazil.
, L.G. Albuquerque Related information1Department of Animal Science, Sao Paulo State University, School of Agriculture and Veterinarian Sciences, Jaboticabal, Brazil.
5Researcher at National Council for Scientific and Technological Development (CNPq), Brasília, Brazil.
, R. Carvalheiro Related information5Researcher at National Council for Scientific and Technological Development (CNPq), Brasília, Brazil.
1Department of Animal Science, Sao Paulo State University, School of Agriculture and Veterinarian Sciences, Jaboticabal, Brazil.
5Researcher at National Council for Scientific and Technological Development (CNPq), Brasília, Brazil.
5Researcher at National Council for Scientific and Technological Development (CNPq), Brasília, Brazil.
Published Online: February 09, 2023
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