Genome-Wide Association Studies (GWAS) help identify polymorphic sites or genes linked to phenotypic variance, but a few genes / SNPs are unlikely to explain the phenotypic variability of complex traits. In the study, the focus was moved from single loci to functional units, expressed by the metabolic pathways (KEGG). Consequently, this study aimed to estimate KEGG effects on stature in three Nordic dairy cattle breeds using SNPs effects from GWAS as the dependent variable. The SNPs were annotated to genes, then the genes to KEGG pathways. The effects of KEGG were estimated separately for each breed using a mixed linear model incorporating the similarity between pathways expressed by common genes. The analysis yielded two conclusions: a single gene in a pathway’s component may have a large impact on the pathway’s overall effect or the high pathway effect may be due to the influence of many genes constituting the pathway.
Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP)
Technical and species orientated innovations in animal breeding, and contribution of genetics to solving societal challenges
EditorsR.F. Veerkamp and Y. de Haas
Published: 2022 Pages: 3364
eISBN: 978-90-8686-940-4
Book Type: Conference Proceedings
512. The application of mixed linear models for the estimation of functional effects on bovine stature based on SNP summary
K. Kotlarz Related information
1Biostatistics Group, Department of Genetics, Wroclaw University of Environmental and Life Sciences, Kozuchowska 7, 51-631 Wroclaw, Poland.
, B. Kosinska-Selbi Related information1Biostatistics Group, Department of Genetics, Wroclaw University of Environmental and Life Sciences, Kozuchowska 7, 51-631 Wroclaw, Poland.
, Z. Cai Related information2Center for Quantitative Genetics and Genomics, Aarhus University, Blichers Allé 20, 8830 Tjele, Denmark.
, G. Sahana Related information2Center for Quantitative Genetics and Genomics, Aarhus University, Blichers Allé 20, 8830 Tjele, Denmark.
, J. Szyda Related information1Biostatistics Group, Department of Genetics, Wroclaw University of Environmental and Life Sciences, Kozuchowska 7, 51-631 Wroclaw, Poland.
3National Research Institute of Animal Production, Krakowska 1, 32-083 Balice, Poland.
*Corresponding author: joanna. szyda@upwr. edu. pl
3National Research Institute of Animal Production, Krakowska 1, 32-083 Balice, Poland.
*Corresponding author: joanna.
Pages: 2126 - 2128
Published Online: February 09, 2023
Abstract: