The use of insects recently emerged as an alternative source of high-quality animal protein for both animal and human food supplementation use with lower environmental impact. Recent evidence indicates that an insect-based diet provides an improved animal production mass gain and showed benefits for human health. The present study evaluated the dietary supplementation effect of the Tenebrio molitor fermented and wholemeal flour on the metabolism of diet-induced obese mice. Male Swiss mice were divided into 4 groups treated for 4 weeks as follows: standard diet, high-fat diet, high-fat diet + wholemeal flour and high-fat diet + fermented flour. The 15% wholemeal or fermented flour were added to the diet. Several parameters such as food/energy intake, body weight, adipose tissue weight, biochemical levels, adipose tissue histology and mRNA expression were evaluated. The main results showed that the inclusion of wholemeal and fermented T. molitor flour induced body weight loss, adiposity reduction and specific changes in biochemical and histological parameters. In addition, was observed significant changes in lipogenic gene expression. The insect flour negatively modulated the expression of the SREBP1α, CEBP1α, FAS, ACC gene and positively modulated PGC1α. In conclusion, the main findings showed the T. molitor flour potential use to improve dyslipidaemia and adiposity with beneficial effects on metabolic diseases.
RESEARCH ARTICLE
Effect of dietary supplementation with Tenebrio molitor wholemeal and fermented flour modulating adipose lipogenesis gene expression in obese mice
B.V. Caldas Related information
1Institute of Agricultural Sciences (ICA), Postgraduate Program in Food and Health, Universidade Federal de Minas Gerais (UFMG), Montes Claros, Minas Gerais, 39.404-54, Brazil.
, V.H.D. Guimarães Related information2Health Science Laboratory, Postgraduate Program in Health Science, Universidade Estadual de Montes Claros (UNIMONTES), Minas Gerais, 3940000, Brazil.
, G.H.M. Ribeiro Related information1Institute of Agricultural Sciences (ICA), Postgraduate Program in Food and Health, Universidade Federal de Minas Gerais (UFMG), Montes Claros, Minas Gerais, 39.404-54, Brazil.
, T.A.X. dos Santos Related information3Faculty of Food Engineering (FEA), Universidade Estadual de Campinas (UNICAMP), São Paulo, 13083-862, Brazil.
, D.A. Nobre Related information3Faculty of Food Engineering (FEA), Universidade Estadual de Campinas (UNICAMP), São Paulo, 13083-862, Brazil.
, R.J.S. de Castro Related information3Faculty of Food Engineering (FEA), Universidade Estadual de Campinas (UNICAMP), São Paulo, 13083-862, Brazil.
, D.V. da Costa Related information1Institute of Agricultural Sciences (ICA), Postgraduate Program in Food and Health, Universidade Federal de Minas Gerais (UFMG), Montes Claros, Minas Gerais, 39.404-54, Brazil.
, A.M.B. de Paula Related information2Health Science Laboratory, Postgraduate Program in Health Science, Universidade Estadual de Montes Claros (UNIMONTES), Minas Gerais, 3940000, Brazil.
, A.L.S. Guimarães Related information2Health Science Laboratory, Postgraduate Program in Health Science, Universidade Estadual de Montes Claros (UNIMONTES), Minas Gerais, 3940000, Brazil.
, V. Mafra Related information2Health Science Laboratory, Postgraduate Program in Health Science, Universidade Estadual de Montes Claros (UNIMONTES), Minas Gerais, 3940000, Brazil.
, J. Cota Related information1Institute of Agricultural Sciences (ICA), Postgraduate Program in Food and Health, Universidade Federal de Minas Gerais (UFMG), Montes Claros, Minas Gerais, 39.404-54, Brazil.
, S.H.S. Santos Related information1Institute of Agricultural Sciences (ICA), Postgraduate Program in Food and Health, Universidade Federal de Minas Gerais (UFMG), Montes Claros, Minas Gerais, 39.404-54, Brazil.
2Health Science Laboratory, Postgraduate Program in Health Science, Universidade Estadual de Montes Claros (UNIMONTES), Minas Gerais, 3940000, Brazil.
*Corresponding author: sergiosousas@hotmail. com
2Health Science Laboratory, Postgraduate Program in Health Science, Universidade Estadual de Montes Claros (UNIMONTES), Minas Gerais, 3940000, Brazil.
*Corresponding author: sergiosousas@hotmail.
Journal of Insects as Food and Feed: 9
(5)- Pages: 625 - 635
Published Online: November 28, 2022
Abstract
Keywords: edible insect, metabolic syndrome, obesity, Tenebrio molitor, fermentation
2022 Journal Impact Factor
5.7
source: Journal Impact Factor 2023™ from Clarivate™
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