Andersen, B., Dongo, A. and Pryor, B.M., 2008. Secondary metabolite profiling of Alternaria dauci, A. porri, A. solani, and A. tomatophila. Mycological Research 112: 241-250. Crossref, Google Scholar
	Arnold, D.L., Scott, P.M., McGuire, P.F., Harwig, J. and Nera, E.A., 1978. Acute toxicity studies on roquefortine and PR toxin, metabolites of Penicillium roqueforti, in the mouse. Food and Cosmetics Toxicology 16: 369-371. Crossref, Google Scholar
	Aujard, C., Morel-Chany, E., Icard, C. and Trincal, G., 1979. Effect of PR toxin on liver cells. Toxicology 12: 313-323. Crossref, Google Scholar
	Boysen, M.E., Jacobsson, K.G. and Schnürer, J., 2000. Molecular identification of species from the Penicillium roqueforti group associated with spoiled animal feed. Applied and Environmental Microbiology 66: 1523-1526. Crossref, Google Scholar
	Boysen, M.E., Skouboe, P., Frisvad, J.C. and Rossen, L., 1996. Reclassification of the Penicillium roqueforti group into three species on the basis of molecular genetic and biochemical profiles. Microbiology 142: 541-549. Crossref, Google Scholar
	Cano, P.M., Jamin, E.L., Tadrist, S., Bourdaud’hui, P., Péan, M., Debrauwer, L., Oswald, I.P., Delaforge, M. and Puel, O., 2013. New untargeted metabolic profiling combining mass spectrometry and isotopic labeling: application on Aspergillus fumigatus grown on wheat. Analytical Chemistry 85: 8412-8420. Crossref, Google Scholar
	Chang, P.K., 2003. The Aspergillus parasiticus protein AFLJ interacts with the aflatoxin pathway-specific regulator AFLR. Molecular Genetics and Genomics 268: 711-719. Crossref, Google Scholar
	Chang, P.K., Cary, J.W., Bhatnagar, D., Cleveland, T.E., Bennett, W., Linz, J.E., Woloshuk, C.P. and Payne, G.A., 1993. Cloning of the Aspergillus parasiticus apa-2 gene associated with the regulation of aflatoxin biosynthesis. Applied and Environmental Microbiology 59: 3273-3279. Crossref, Google Scholar
	Chang, S.C., Yeh, S.F., Li, S.Y., Lei, W.Y. and Chen, M.Y., 1996. A novel secondary metabolite relative to the degradation of PR toxin by Penicillium roqueforti. Current Microbiology 32: 141-146. Crossref, Google Scholar
	Chanput, W., Mes, J.J. and Wichers, H.J., 2014. THP-1 cell line: an in vitro cell model for immune modulation approach. International Immunopharmacology 23: 37-45. Crossref, Google Scholar
	Chanput, W., Mes, J.J., Vreeburg, R.A.M., Savelkoul, H.F.J. and Wichers, H.J., 2010. Transcription profiles of LPS-stimulated THP-1 monocytes and macrophages: a tool to study inflammation modulating effects of food-derived compounds. Food and Function 1: 254-261. Crossref, Google Scholar
	Cheli, F., Campagnoli, A. and Dell’Orto, V., 2013. Fungal populations and mycotoxins in silages: from occurrence to analysis. Animal Feed Science Technology 183: 1-16. Crossref, Google Scholar
	Chen, F.C., Chen, C.F. and Wei, R.D., 1982. Acute toxicity of PR toxin, a mycotoxin from Penicillium roqueforti. Toxicon 20: 433-441. Crossref, Google Scholar
	Fontaine, K., Hymery, N., Lacroix, M., Puel, S., Puel, O., Rigalma, K., Gaydou, V., Coton, E. and Mounier, J., 2015. Influence of intraspecific variability and abiotic factors on mycotoxin production in Penicillium roqueforti. International Journal of Food Microbiology 215: 187-193. Crossref, Google Scholar
	Fontaine, K., Mounier, J., Coton, E. and Hymery, N., 2016. Individual and combined effects of roquefortine C and mycophenolic acid on human monocytic and intestinal cells. World Mycotoxin Journal 9: 41-51. Google Scholar
	Frisvad, J.C., Andersen, B. and Thrane, U., 2008. The use of secondary metabolite profiling in fungal taxonomy. Mycology Research 112: 231-240. Crossref, Google Scholar
	Frisvad, J.C., Rank, C., Nielsen, K.F. and Larsen, T.O., 2009. Metabolomics of Aspergillus fumigatus. Medical Mycology 47: S53-S71. Crossref, Google Scholar
	Furtado, N., Said, S., Ito, I.Y. and Bastos, J.K., 2002. The antimicrobial activity of Aspergillus fumigatus is enhanced by a pool of bacteria. Microbiology Research 157: 207-211. Google Scholar
	Gallo, A., Giuberti, G., Frisvad, J.C., Bertuzzi, T. and Nielsen, K.F., 2015. Review on mycotoxin issues in ruminants: occurrence in forages, effects of mycotoxin ingestion on health status and animal performance and practical strategies to counteract their negative effects. Toxins 7: 3057-3111. Crossref, Google Scholar
	Gillot, G., Jany, J.L., Dominguez-Santos, R., Poirier, E., Debaets, S., Hidalgo, P., Ullán, R., Coton, E. and Coton, M., 2017. Genetic basis for mycophenolic acid production and strain-dependent production variability in Penicillium roqueforti. Food Microbiology 62: 239-250. Crossref, Google Scholar
	Hidalgo, P., Poirier, E., Ullán, R., Piqueras, J., Meslet-Cladière, L., Coton, E. and Coton, M., 2016. Penicillium roqueforti PR toxin gene cluster characterization. Applied Microbiology and Biotechnology 101: 2043-2056. Crossref, Google Scholar
	Hidalgo, P.I., Ullán, R.V., Albillos, S.M., Montero, O., Fernández-Bodega, M.Á., García-Estrada, C., Fernández-Aguado, M. and Martín, J.F., 2014. Molecular characterization of the PR-toxin gene cluster in Penicillium roqueforti and Penicillium chrysogenum: cross talk of secondary metabolite pathways. Fungal Genetics Biology 62: 11-24. Crossref, Google Scholar
	Hymery, N., Masson, F., Barbier, G. and Coton, E., 2014. Cytotoxicity and immunotoxicity of cyclopiazonic acid on human cells. Toxicology in Vitro 28: 940-947. Crossref, Google Scholar
	Jonsson, M., Jestoi, M., Anthoni, M., Welling, A., Loivamaa, I., Hallikainen, V., Kankainen, M., Lysøe, E., Koivisto, P. and Peltonen, K., 2016. Fusarium mycotoxin enniatin B: cytotoxic effects and changes in gene expression profile. Toxicology in Vitro 34: 309-320. Crossref, Google Scholar
	Keblys, M., Bernhoft, A., Hofer, C.C., Morrison, E., Larsen, H.J. and Flaoyen, A., 2004. The effects of the Penicillium mycotoxins citrinin, cyclopiazonic acid, ochratoxin A, patulin, penicillic acid, and roquefortine C on in vitro proliferation of porcine lymphocytes. Mycopathologia 158: 317-324. Crossref, Google Scholar
	Lavermicocca, P., Valerio, F. and Visconti, A., 2003. Antifungal activity of phenyllactic acid against molds isolated from bakery products. Applied and Environmental Microbiology 69: 1634-1640. Google Scholar
	Le Bars, J. and Le Bars, P., 1989. Espèces fongiques des ensilages de maïs. Risques mycotoxiques. Recueil de Medecine Veterinaire 165: 433-439. Google Scholar
	Le Ferrec, E., Chesne, C., Artusson, P., Brayden, D., Fabre, G., Gires, P., Guillou, F., Rousset, M., Rubas, W. and Scarino, M.L., 2001. In vitro models of the intestinal barrier. The report and recommendations of ECVAM Workshop 46. European Centre for the Validation of Alternative methods. Alternatives to Laboratory Animals 29: 649-668. Crossref, Google Scholar
	Livak, K.J. and Schmittgen, T.D., 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCT method. Methods 25: 402-408. Crossref, Google Scholar
	Lund, F., Filtenborg, O., Westall, S. and Frisvad, J.C., 1996. Associated mycoflora of rye bread. Letters in Applied Microbiology 23: 213-217. Crossref, Google Scholar
	Maess, M.B., Sendelbach, S. and Lorkowski, S., 2010. Selection of reliable reference genes during THP-1 monocyte differentiation into macrophages. BMC Molecular Biology 11: 90-98. Crossref, Google Scholar
	Martín, J.F. and Coton, M., 2017. Blue cheese: microbiota and fungal metabolites. In: Frias, J., Martínez-Villaluenga, C. and Peñas, E. (eds.) Fermented foods in health and disease prevention. Elsevier, New York, NY, USA, pp. 275-303. Google Scholar
	Moulé, Y., Jemmali, M. and Rousseau, N., 1976. Mechanism of the inhibition of transcription by PR toxin, a mycotoxin from Penicillium roqueforti. Chemico-Biological Interactions 14: 207-216. Crossref, Google Scholar
	Moulé, Y., Moreau, S. and Aujard, C., 1980. Induction of cross-links between DNA and protein by PR toxin, a mycotoxin from Penicillium roqueforti. Mutation Research 77: 1-97. Google Scholar
	Muller, G., Rosner, H., Rohrmann, B., Erler, W., Geschwend, G., Gräfe, U., Burkert, B., Möller, U., Diller, R., Sachse, K. and Köhler, H., 2003. Effects of the mycotoxin ochratoxin A and some of its metabolites on the human cell line THP-1. Toxicology 184: 69-82. Crossref, Google Scholar
	Nielsen, K., Nielsen, O.G., Sumarah, M.W., Frisvad, J.C. and Miller, J.D., 2006. Production of metabolites from the Penicillium roqueforti complex. Journal of Agricultural and Food Chemistry 54: 3756-3763. Crossref, Google Scholar
	Nielsen, T.S., Sørensen, I.F., Sørensen, J.L., Søndergaard, T.E. and Purup, S., 2016. Cytotoxic and apoptotic effect of mycotoxins in human small intestinal cells 1. Journal of Animal Science 94 (Suppl. 3): 234-237. Crossref, Google Scholar
	Oh, S.Y., Boermans, H.J. and Swamy, H.V.L.N., 2012. Immunotoxicity of Penicillium mycotoxins on viability and proliferation of bovine macrophage cell line (BOMACs). Open Mycology Journal 6: 11-16. Crossref, Google Scholar
	Pedrosa, K. and Griessler, K., 2010. Toxicity, occurrence and negative effects of PR toxin – the hidden enemy. International Dairy Topics 9: 7-9. Google Scholar
	Pinton, P. and Oswald, I., 2014. Effect of deoxynivalenol and other type B trichothecenes on the intestine: a review. Toxins 6: 1615-1643. Crossref, Google Scholar
	Pistol, G.C., Gras, M.A., Marin, D.E., Israel-Roming, F., Stancu, M. and Taranu, I., 2014. Natural feed contaminant zearalenone decreases the expressions of important pro- and anti-inflammatory mediators and mitogen-activated protein kinase/NF-kappaB signalling molecules in pigs. British Journal of Nutrition 111: 452-464. Crossref, Google Scholar
	Pitt, J.I. and Hocking, A.D., 2009. Fungi and food spoilage. Springer, New York, NY, USA. Google Scholar
	Prosperini, A., Font, G. and Ruiz, M.J., 2014. Interaction effects of Fusarium enniatins (A, A1, B and B1) combinations on in vitro cytotoxicity of Caco-2 cells. Toxicology in Vitro 28: 88-94. Crossref, Google Scholar
	Rasmussen, R.R., Rasmussen, P.H., Larsen, T.O., Bladt, T.T. and Binderup, M.L., 2011. In vitro cytotoxicity of fungi spoiling maize silage. Food and Chemical Toxicology 49: 31-44. Crossref, Google Scholar
	Richard, E., Heutte, N., Bouchart, V. and Garon, D., 2009. Evaluation of fungal contamination and mycotoxin production in maize silage. Animal Feed Science and Technology 148: 309-320. Crossref, Google Scholar
	Riclea, R. and Dickschat, J.S., 2015. Identification of intermediates in the biosynthesis of PR toxin by Penicillium roqueforti. Angewandte Chemie International, English edition 54: 12167-12170. Crossref, Google Scholar
	Ropars, J., Cruaud, C., Lacoste, S. and Dupont, J., 2012. A taxonomic and ecological overview of cheese fungi. International Journal of Food Microbiology 155: 199-210. Crossref, Google Scholar
	Schneweis, I., Meyer, K., Hörmansdorfer, S. and Bauer, J., 2000. Mycophenolic acid in silage. Applied and Environmental Microbiology 66: 3639-3641. Crossref, Google Scholar
	Scudamore, K.A. and Livesey, C.T., 1998. Occurrence and significance of mycotoxins in forage crops and silage: a review. Journal of the Science of Food and Agriculture 77: 1-17. Crossref, Google Scholar
	Skaar, I., 1996. Mycological survey and characterization of the microbiota of big bale grass silage. PhD-thesis, Norwegian College of Veterinary Medicine, Oslo, Norway. Google Scholar
	Solhaug, A., Eriksen, G.S. and Holme, J.A., 2016. Mechanisms of action and toxicity of the mycotoxin alternariol: a review. Basic and Clinical Pharmacology and Toxicology 119: 533-539. Crossref, Google Scholar
	Stec, J., Zmudzki, J., Rachubik, J. and Szczotka, M., 2009. Effects of aflatoxin B1, ochratoxin A, patulin, citrinin, and zearalenone on the in vitro proliferation of pig blood lymphocytes. Bulletin of Veterinary Institut of Pulawy 53: 129-134. Google Scholar
	Still, P., Wei, R., Smalley, E. and Strong, F., 1972. A mycotoxin from Penicillium roqueforti isolated from toxic cattle feed. Federation Proceedings 31: 733. Google Scholar
	Storm, I.M.L.D., Kristensen, N.B., Raun, B.M.L., Smedsgaard, J. and Thrane, U., 2010. Dynamics in the microbiology of maize silage during whole-season storage. Journal of Applied Microbiology 109: 1017-1026. Crossref, Google Scholar
	Sumarah, M.W, Miller, J.D. and Blackwell, B.A., 2005. Isolation and metabolite production by Penicillium roqueforti, P.paneum and P.crustosum isolated in Canada. Mycopathologia 159: 571-577. Crossref, Google Scholar
	Veselý, D., Veselá, D. and Adámková, N., 1981. Occurrence of PR toxin-producing Penicillium roqueforti in corn silage. Veterinary Medicine Czech 26: 109-115. Google Scholar
	Wei, R.D., Schnoes, H.K., Hart, P.A. and Strong, F.M., 1975. The structure of PR toxin, a mycotoxin from Penicillium roqueforti. Tetrahedron 31: 109-114. Crossref, Google Scholar
	Wei R.D., Schnoes, H.K., Smalley, E.B., Lee, S.S., Chang, Y.N. and Strong, F.M., 1976. Production, isolation, chemistry, and biological properties of Penicillium roqueforti toxin. In: Ohaska, A., Hayashi, K. and Sawai, Y. (eds.) Animal, plant, and microbial toxins. Vol. 2. Plenum Press, New York, NY, USA, pp. 137-144. Google Scholar
	Wei, R.D., Still, P.E., Smalley, E.B., Schnoes, H.K. and Strong, F.M. 1973. Isolation and partial characterization of a mycotoxin from Penicillium roqueforti. Applied Microbiology 25: 111-114. Crossref, Google Scholar
	Wei, Y.H., Ding, W.H. and Wei, R.D., 1984. Biochemical effects of PR toxin on rat liver mitochondrial respiration and oxidative phosphorylation. Archives of Biochemistry and Biophysics 230: 400-411. Crossref, Google Scholar
	Zain, M.E., 2011. Impact of mycotoxins on humans and animals. Journal of Saudi Chemical Society 15: 129-144. Crossref, Google Scholar